Vince Blake first appeared in "The Great Vince Blake", and he is a young football prodigy, who is supposed to be the best high school quarterback in the country. He's very popular at PCA, a chick magnet, and a hero which many other guys look up to. Chase seemed to be the only one bothered by his special attention and popularity. However, Vince was found out to be very dishonest, as Chase caught him cheating on a test. Chase ended up turning him in, causing Vince to be put on academic probation. Enraged, he rounded up the football team and beat up Chase, along with Michael, Logan, and Mark Del Figgalo, who came by to stand up to them with Chase. Henceforth, he was expelled from PCA.
He returned in the episode "Vince is Back", and appears to have had a change of heart. The guys wanted to get revenge on him, while the girls chose to just ignore him, but Lola ran into him, and even tried to ignore him. However, she couldn't resist how nice he had become, and ended up kissing him four times. They've since become a couple. Michael, Logan, and the girls forgave him, and have now become good friends with him.
In the episode "Coffee Cart Ban" he was one of the first people to find out about Logan and Michael's illegal coffee business and notified Lola and the girls about it.
In "Chasing Zoey" Vince takes Lola to one of her favorite restaurants before the prom, but after the cab driver angrily abandons the car and the keys he and Lola are stranded. They try to find a way to PCA through the woods and run into FireWire and the rest of his nerd friends who they follow and manage to get to prom right before it ends. We last see Vince dancing with Lola and all the rest of their friends at prom.